Bim Graham

Lecturer

B.Sc (Hons). PhD (Monash), MRACI.

Phone: +61 9903 9706
Fax: +61 9903 9582
email: Bim.Graham@pharm.monash.edu.au

Research Interests

•  Recognition of biologically-important anions by metal-based receptors
•  Development of metal-containing nucleic acid mimics for anti-sense therapy
•  Design and synthesis of metal complexes for anti-HIV therapy
•  Application of metal complexes as artificial enzymes
•  Development of metal complex-biomolecule hybrids for tumour imaging

Honours projects for 2008

• G-quadruplex-stabilising agents with potential anti-cancer activity
• "Nanozymes": functionalised dendrimers as enzyme mimics
• Novel chemosensors for assay of protein kinase activity
• Synthetic ion channels with potential anti-bacterial activity

Significant Publications

1. B. Graham, M. T. W. Hearn, P. C. Junk, C. M. Kepert, F. E. Mabbs, B. Moubaraki, K. S. Murray, L. Spiccia, Syntheses, crystal structures, magnetic properties, and EPR spectra of tetranuclear copper(II) complexes featuring pairs of "roof-shaped" Cu2X2 dimers with hydroxide, methoxide and azide bridges, Inorg. Chem., 2001, 40, 1536-1543. 
2. Warden, B. Graham, M. T. W. Hearn, L. Spiccia, Synthesis of novel derivatives of 1,4,7-triazacyclononane, Org. Lett., 2001, 3, 2855-2858. 
3. B. Graham, M. T. W. Hearn, L. Spiccia, B. W. Skelton, A. H. White, Amino acid binding to copper(II) in (1,4,7-triazacyclononane)(L-histidine)copper(II) hexafluorophosphate monohydrate, Aust. J. Chem., 2003, 56, 1259-1261. 
4. G. Gasser, A. M. Bond, B. Graham, Z. Kosowski, L. Spiccia, Synthesis of new metal complex-biomolecule hybrids as redox sensors for specific nucleobases, NSTI-Nanotech, 2005, 1, 412-415. 
5. B. Graham, L. Spiccia, B. W. Skelton, A. H. White, D. C. R. Hockless, Imidazole derivatives of binuclear copper(II) and nickel(II) complexes incorporating bis(1,4,7-triazacyclononan-1-yl) ligands, Inorg. Chim. Acta, 2005, 358, 3974-3982. 
6. M. J. Belousoff, M. B. Duriska, B. Graham, S. R. Batten, B. Moubaraki, K. S. Murray, L. Spiccia, Synthesis, structure, magnetism and phosphate ester cleavage properties of copper(II) complexes of N-substituted derivatives of 1,4,7-triazacyclononane, Inorg. Chem., 2006, advance article.