Centre for Drug Candidate Optimisation - Significant Publications

D.J. Creek, W.N. Charman, F.C.K. Chiu, R.J. Prankerd, K.J. McCullough, Y. Dong, J.L. Vennerstrom and S.A. Charman. Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials. J. Pharm. Sci., in press

Y. Tang, Y. Dong, S. Wittlin,  J. Chollet, S.A. Charman, F.C.K. Chiu, W.N. Charman, H. Matile, H. Urwyler, A. Dorn, J. Santo Tomas, C. Scheurer, C. Snyder, S. Bajpai, X. Wang, M. Padmanilayam, J.M. Karle, B. Scorneaux, R. Brun., and J.L. Vennerstrom. Weak Base Dispiro-1,2,4-Trioxolanes: Potent Antimalarial Ozonides. Bioorg. Med. Chem. Lett., 17, 1260-1265, 2007.

M. Padmanilayam, B. Scorneaux, Y. Dong, J. Chollet, H. Matile, S.A. Charman,  W.N. Charman,  J. Santo Tomas, C. Scheurer, S. Wittlin,  R. Brun, and J.L. Vennerstrom. Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide and urea derivatives of a dispiro-1,2,4-trioxolane piperidine. Bioorg. Med. Chem. Lett., 16, 5542-5545, 2006.

Y. Dong, Y. Tang, J. Chollet, H. Matile, S. Wittlin, S.A. Charman,  W.N. Charman, J. Santo Tomas, C. Scheurer, C. Snyder, B. Scorneaux,  S. Bajpai, S.A. Alexander, X. Wang, M. Padmanilayam, C.S. Rao, R. Brun, and J.L. Vennerstrom. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes. Bioorg. Med. Chem., 14, 6368-6382, 2006.

S. Maerki, R. Brun, S. Charman, A. Dorn, H. Matile, S. Wittlin. In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277 / RBx-11160 in cultures of Plasmodium falciparum. J. Antimicrob.Chemother., 58, 52-58, 2006.

C.S. Perry, S.A. Charman, R.J. Prankerd, F.C.K. Chiu, Y. Dong, J.L. Vennerstrom and W.N. Charman. Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials. J. Pharm. Sci., 95, 737-747, 2006.

J. Nicolazzo, S.A. Charman, W.N. Charman. Methods to assess drug permeability through the blood-brain barrier. J. Pharm Pharmacol, 58, 281-293, 2006.

C.S. Perry, F.C.K. Chiu, K.A. McIntosh, R.J. Prankerd, W.N. Charman and S.A. Charman. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J. Pharm. Sci., 95, 256-267, 2006.

C.S. Perry, S.A. Charman, R.J. Prankerd, F.C.K. Chiu, M.J. Scanlon, D. Chalmers and W.N. Charman. The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins. J. Pharm. Sci., 95, 146-158, 2006.

Y. Dong, J. Chollet, H. Matile, S.A. Charman, F.C.K. Chiu, W.N. Charman, B. Scorneaux, H. Urwyler, J. Santo Tomas, C. Scheurer, A. Dorn, X. Wang, J.M. Karle, Y. Tang, S. Wittlin, R. Brun, and J.L. Vennerstrom. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable SAR using simple prototypes. J. Med. Chem., 48, 4953-4961, 2005.

D.J. Creek, F.C.K. Chiu, R.J. Prankerd, S.A. Charman and W.N. Charman. Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt. J. Pharm. Sci., 94, 1820-1829, 2005.