X-ray diffraction Facility

The structural biology laboratory was completed in early 1999 and houses a state-of-the-art macromolecular X-ray diffraction facility. Major data collection equipment includes a Rigaku-RU300 rotating anode generator with a MAR-345 image plate detector system, focusing mirror system, Oxford cryogenic low temperature system and SGI O2 workstations for data analysis and interpretation. Research areas include the elucidation of 3D structures of several protein targets for structure based drug design. Once the crystal structure of a target enzyme is known, the structure will be used to obtain a 3D structure of the protein-ligand complex. The results of this analysis will allow the modification of the ligand in order to overcome deficiencies without interfering with its ability to interact with the target protein.

If you would like more information regarding the X-ray diffraction facility please contact Dr Ossama El-Kabbani.