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Ben Capuano

Photo of Dr Capuano

Lecturer

B. App. Sci. (App. Chem.) RMIT (1987),
M. Pharm., Vic. Coll. Pharmacy, (1991),
Ph.D., Monash University, (2001).

Phone: +61 3 9903 9556
Fax: +61 3 9903 9582
email: Ben.Capuano@pharm.monash.edu.au

Research Experience

  • The design, synthesis and biological evaluation of novel antipsychotics for the treatment of schizophrenia.
  • The design, synthesis and pharmacological evaluation of potential anti-Parkinson agents.
  • Chemotherapeutic activity of synthetic phenothiazines, dibenzodiazepines and related tricyclic structural motifs.

Honours projects for 2008

Significant Publications

  1. I. T.; Lim, S. E. K.; Lloyd, E. J.; Yuriev, E.  Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine. Molbank, 2006, M475, 1-2.
  2. Camerino, M. A.; Capuano, B.; Crosby, I. T.; Lloyd, E. J.  Synthesis of benzyl 2-(4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazin-1-yl)acetate. Molbank, 2005, M453, 1-2.
  3. Capuano, B.; Crosby, I. T.; Egan, S. J.; Fallon, G. D.; Lloyd, E. J.; Neve, J. E.
    4-Chloro-N-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazinio]benzamidate dichloromethane solvate.  Acta Cryst. 2005. E61, o20-o22.
  4. Capuano, B.; Crosby, I. T.; Lloyd, E. J; Podloucka, A.; Taylor, D. A.  Synthesis and Preliminary Pharmacological Evaluation of Novel Antipsychotics  for the Treatment of Schizophrenia.  Drugs Fut. 2004, 29 (Suppl. A): P343.
  5. Capuano, B.; Crosby, I. T.; Lloyd, E. J.; Podloucka, A.; Taylor, D. A.  Synthesis and Preliminary Pharmacological Evaluation of 4' Arylalkyl Analogues of Clozapine. II. Effect of the Nature and Length of the Linker. Aust. J. Chem., 2003, 56, 875-886.
  6. B. Capuano, I. T. Crosby, G. D. Fallon, E. J..Lloyd, E. Yuriev and S. J. Egan.       2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate monohydrate (olanzapine, ZyprexaTM). Acta Cryst., 2003, E56, o1367-o1369.
  7. Capuano, B.; Crosby, I. T.; Lloyd, E. J.; Taylor, D. A.  Synthesis and Preliminary Pharmacological Evaluation of 4' Arylmethyl Analogues of Clozapine. I. The Effect of Aromatic Substituents. Aust. J. Chem., 2002, 55, 565-576.
  8. Capuano, B.; Crosby, I. T.; Lloyd, E. J.  Schizophrenia: Genesis, Receptorology and Current Therapeutics. Curr. Med. Chem. 2002, 9 (5), 521-548.