Skip to content | Change text size
 

Jamie Simpson

Dr Simpson, Lecturer, Medicinal Chemistry

Lecturer

B.Sc. (Hons), PhD (Qld), MRACI.

Phone: +61 9903 9636
Fax: +61 9903 9582
email: Jamie.Simpson@pharm.monash.edu.au

Research Interests

  • Enzymes involved in vitamin biosynthesis
  • Marine natural products chemistry and the biosynthesis of marine natural products
  • Fragment-based approaches to drug discovery
  • Amino acid chemistry
  • Cyclodextrins as enzyme mimics

Honours projects for 2008

Significant Publications

  1. O’Connell, J.L., Simpson, J.S., Dumanski, P.D., Simpson, G.W., and Easton, C.J., ‘Aromatic chlorination of w-phenylalkylamines and w-phenylalkylamides in carbon tetrachloride and a,a,a-trifluorotoluene.’ Org. Biomol. Chem., 2006, 4, 2716–2723.
  2. Barratt, B.J., Easton, C.J., Henry, D.J., Li, I.H.W., Radom, L., and Simpson, J.S., ‘Inhibition of Peptidylglycine alpha-Hydroxylating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals.’ J. Am. Chem. Soc., 2004, 126(41), 13306-13311.
  3. Garson, M.J., and Simpson, J.S., ‘Marine Isocyanides and Related Natural Products – Structure, Biosynthesis and Ecology.’ Nat. Prod. Rep., 2004, 21, 164-179.
  4. Simpson, J.S., and Garson, M.J., ‘Biosynthetic Pathways to Isocyanides and Isothiocyanates; Precursor Incorporation Studies on Terpene Metabolites in the Tropical Marine Sponges Amphimedon terpenensis and Axinyssa n.sp.’, Org. Biomol. Chem., 2004, 2, 949-956.
  5. Simpson, J.S., Brust, A., and Garson, M.J., ‘Biosynthetic Pathways to Dichloroimines in Marine Sponges: Precursor Incorporation Studies on Terpene Metabolites in the Tropical Marine Sponge Stylotella aurantium.’, Org. Biomol. Chem., 2004, 2, 939-948.
  6. Dumanski, P.D., Easton, C.J., Lincoln, S.F., and Simpson, J.S., ‘Effect of Cyclodextrins on Electrophilic Aromatic Bromination in Aqueous Solution’ Aust. J. Chem., 2003, 56, 1107-1111.
  7. Easton, C.J., Edwards, A., McNabb, S.B., Merrett, M.C., O’Connell, J.L., Simpson, G.W., Simpson, J.S., and Willis, A.C., ‘Allylic Halogenation of Unsaturated Amino Acids’ Org. Biomol. Chem., 2003, 1, 2492–2498