James Swarbrick

Lecturer

BSc(Hons), Grey faculty, Durham University, UK
PhD, Newcastle University, UK

Phone: +61 9903 9543
Fax: +61 9903 9582
email: James.Swarbrick@pharm.monash.edu.au

Research Interests

Using NMR Spectroscopy for:

• Protein structure determination – Systems include the transcription factor TyrR and the Nudix Hydrolases. Modern methods.
• Lead Compound design. Development of novel inhibitors of the Folate pathway enzymes using Fragment based screening and Saturation Transfer Difference (STD) NMR. Collaboration with Prof. Peter Scammells (VCP) and Prof. Ian Macreadie (CSIRO).
• Small molecule conformational and configurational analysis in partially aligned media using residual dipolar couplings.

Honours projects for 2008

• New antimicrobials from the folate pathway:Targeting Dihydropteroate Synthase (DHPS)

Significant Publications

• Swarbrick J. D. et al. Structure and Substrate-binding mechanism of human Ap₄A hydrolase. J. Biol. Chem. 2005 280(9) 8471-81.
• Swarbrick J. D. et al. Backbone resonance assignment of the ²H, ¹³C, ¹⁵N labelled 32kDa central domain of Escherichia coli TyrR. J. Biomol NMR 2002 22(4) 381-2
• Fletcher J. I., Swarbrick J.D. et al. The structure of Ap₄A hydrolase complexed with ATP-MgF(x) reveals the basis of substrate binding. Structure. 2002 10(2), 205-13.
• Swarbrick J.D. et al. The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L. J. Mol. Biol. 2000 302(5). 1165-77.