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Ossama El-Kabbani

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Associate Professor

B.Sc. (Hons), University of Alexandria (Egypt); PhD, University of Saskatchewan (Canada)

Phone: +61 3 9903 9691
Fax: +61 3 9903 9582
email: Ossama.El-Kabbani@pharm.monash.edu.au

Research Interests

  • Protein expression and purification
  • Protein X-ray crystallography
  • Protein/ligand and protein/protein docking
  • Structure-based drug design
  • Enzyme catalysis and mechanism
  • Discovery of novel enzyme inhibitors by virtual screening

Honours projects for 2008

Significant Publications

  1. Fenalti, G., Hampe, C.S., O’Connor, K., Banga, J.P., Mackay, I.R., Rowley, M.J. and El-Kabbani, O.  Molecular Characterisation of a Disease Associated Conformational Epitope on GAD65 Recognised by a Human Monoclonal Antibody b96.11. Molecular Immunology 44: 1178-1189, 2007.
  2. O’Connor, K.H., Banga, J.P., Darmanin, C., El-Kabbani, O., Mackay, I. and Rowley, M.J.  Characterisation of an Autoreactive Conformational Epitope on GAD65 Recognised by the Human Monoclonal Antibody b78 Using a Combination of Phage Display, In Vitro Mutagenesis and Molecular Modelling.  Journal of Autoimmunity 26: 172-181, 2006.
  3. Darmanin, C., Iwata, T., Carper, D. and El-Kabbani, O. Discovery of Potential Sorbitol Dehydrogenase Inhibitors from Virtual Screening.  Medicinal Chemistry 2: 239-242, 2006.
  4. El-Kabbani, O., Carbone, V., Darmanin, C., Oka, M., Mitschler, A., Podjarny, A., Schulze-Briese, C. and Chung, R.P.-T. Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity.  Journal of Medicinal Chemistry 48: 5536-5542, 2005.
  5. El-Kabbani, O., Carbone, V. Darmanin, C., Ishikura, S. and Hara, A. Structure of the Tetrameric form of Human L-Xylulose Reductase: Probing the Inhibitor-Binding Site with Molecular Modelling and Site-Directed Mutagenesis.  Proteins: Structure, Function and Bioinformatics 60: 424-432, 2005.
  6. Carbone, V., Ishikura, S., Hara, A. and El-Kabbani, O. Structure-Based Discovery of Human L-Xylulose Reductase Inhibitors from Database Screening and Molecular Docking. Bioorganic and Medicinal Chemistry 13: 301-312, 2005.
  7. El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R.P.-T., Usami, N. and Hara, A. Crystal Structure of Human L-Xylulose Reductase Holoenzyme: Probing the Role of Asn107 with Site-Directed Mutagenesis.  Proteins: Structure, Function and Bioinformatics 55: 724-732, 2004.
  8. El-Kabbani, O., Darmanin, C., Schneider, T.R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A. and Podjarny, A.  Ultra-High Resolution Drug Design II: Atomic Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Fidarestat and Minalrestat: Implications for the Binding of Cyclic Imide Inhibitors. Proteins: Structure, Function and Bioinformatics 55: 805-813, 2004.
  9. El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A. and Podjarny, A.  High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction Between the Enzyme and a Cyclic Imide Type Inhibitor. Journal of Medicinal Chemistry 47: 4530-4537, 2004.
  10. Darmanin, C., Chevreux, G., Potier, N., Van Dorsselaer, A., Hazemann, I., Podjarny, A. and El-Kabbani, O. Probing the Ultra-High Resolution Structure of Aldose Reductase with Molecular Modelling and Noncovalent Mass Spectrometry.  Bioorganic and Medicinal Chemistry 12: 3797-3806, 2004.

Other Information

Bio21 Collaborative Crystallisation Centre - Management Committee Member and CI. For further details please refer to website http://www.csiro.au/c3/