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Philip Thompson

Photo of Dr Thompson

Senior Lecturer

BSc Hons. University of Melbourne
PhD University of Melbourne

Phone: +61 3 9903 9672
Fax: +61 3 9903 9582
email: Phil.Thompson@pharm.monash.edu.au

Research Interests

  • Novel peptidomimetics based upon conformationally defined scaffolds
  • Small molecule inhibitors of cyclic nucleotide phosphodiesterases (PDEs)
  • Small molecule inhibitors of protein and lipid kinases
  • Synthetic peptides for the analysis of protein-protein interactions
  • Novel therapies for thrombosis, diabetes, cancer or inflammatory diseases

Significant Publications

  1. Analysis of anti-PDE3 activity of 2-morpholiochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bio-org. Med. Chem. Letters 2006, 16, 969-973.
  2. The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate selectivity of Phosphodiesterases, Manallack, D., Hughes, R. A., Thompson, P.E. J. Med. Chem.,2005, 48, 3449-3462.
  3. PI 3-kinase p110β: a new target for antithrombotic therapy.  Jackson, S. P., Schoenwalder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L., Wright, C. E., Kenche, V., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S., Angus, J. A., Robertson, A. D., Salem, H. H. Nature Medicine, 2005, 11, 507-514.
  4. Preparation of morpholinyl- and pyridinyl-substituted heterobicyclic ketones as selective inhibitors of phosphoinositide 3-kinase ß for use against thrombosis.Jackson, S. P.; Robertson, A. D.; Kenche, V.; Thompson, P.; Prabaharan, H.; Anderson, K.; Abbott, B.; Goncalves, I.; Nesbitt, W.; Schoenwaelder, S.; Saylik, D., PCT Int. Appl. (2004), WO 2004016607
  5. Cranmer, S.L., Pikovski, I.,  Mangin, P.,Domagala, T., Thompson, P.E., Frazzetto, M.,Salem, H.H., Jackson, S.P., Biochem. J. 2005, 387, 849-858. Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibα..
  6. Abbott, B., Thompson, P.E. Anal. Biochem. 339, 185-187, 2005. A reversed-phase HPLC-base method for the assay of cyclic nucleotide phosphodiesterase activity.