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Dr Joseph A. Nicolazzo

Lecturer in Drug Delivery

BPharm, BPharmSci (Hons), PhD, Monash University, Melbourne

Phone: +61 3 9903 9605
Fax: + 61 3 9903 9583
Email:joseph.nicolazzo@pharm.monash.edu.au

General Research Interests

  • Enhancement of local drug delivery to the buccal mucosa
  • Central nervous system (CNS) drug delivery and factors affecting drug permeability across the blood-brain barrier (BBB)
  • The role of BBB transport proteins on drug disposition into the CNS
  • The impact of various CNS diseases on inherent BBB permeability and transporter expression and function at the BBB

Significant Publications

  1. Nicolazzo, J.A., Finnin, B.C. In vivo and in vitro models for assessing drug absorption across the buccal mucosa. (2008) Biotechnology: Pharmaceutical Aspects. Drug Absorption Studies, in situ, in vitro and silico models89-111.
  2. Nicolazzo, J.A., Nguyen, T., Katneni, K., Steuten, J., Smith, G., Jarrott, B., Callaway, J., Charman, S.A. Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats. (2008) Journal of Pharmacy and Pharmacology 60171-178.
  3. Nicolazzo, J.A., Charman, S.A., Charman, W.N. Methods to assess drug permeability across the blood-brain barrier. (2006) Journal of Pharmacy and Pharmacology 58281-293.
  4. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide. (2005) Journal of Controlled Release 105240-248.
  5. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. Buccal penetration enhancers - How do they really work? (2005) Journal of Controlled Release 1051-15. 
  6. Nicolazzo, J.A., Morgan, T.M., Reed, B.L., Finnin, B.C. Synergistic enhancement of testosterone transdermal delivery. Journal of Controlled Release 103577-585.
  7. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. Enhanced buccal mucosal retention and reduced buccal permeability of estradiol in the presence of padimate O and Azone® - a mechanistic study. (2005) Journal of Pharmaceutical Sciences 94873-882.
  8. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. Modification of buccal drug delivery following pretreatment with skin penetration enhancers. (2004) Journal of Pharmaceutical Sciences 932054-2063.
  9. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. Assessment of the effects of sodium dodecyl sulfate on the buccal permeability of caffeine and estradiol. (2004) Journal of Pharmaceutical Sciences 93431-440.
  10. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. The potential of the buccal mucosa as a site for systemic drug delivery. (2003) Journal of Dental Research 82 (Sp Iss C)101.
  11. Nicolazzo, J.A., Reed, B.L., Finnin, B.C. The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa. (2003) Journal of Pharmaceutical Sciences 924399-2410.