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Dr Michelle P. McIntosh

Senior Lecturer in Pharmaceutics

BPharm(Hons), PhD, Monash University

Phone: +61 3 9903 9531
Fax: + 61 3 9903 9583
Email: michelle.mcintosh@pharm.monash.edu.au

General Research Interests

  • Systemic drug delivery of proteins, peptides and small molecules via the lungs
  • Factors affecting drug delivery to the lungs
  • Pharmacokinetic and pharmacodynamic modelling of pharmaceuticals
  • Drug delivery and efficacy in autoimmune disorders

Significant Publications

  1. Lucas, A.N., Tanol, M., McIntosh, M.P. and Rajewski, R.A. Preparation and purification of desethylamiodarone hydrochloride. (2006) Synthetic Communications, 36: 3371-3376.
  2. Yasuji, T., Haslam, J., Kajiyama, A., McIntosh, M.P. and Rajewski, R.A. Preliminary evaluation of polymer-based drug composite microparticle production by coacervate desolvation with supercritical carbon dioxide. (2006) Journal of Pharmaceutical Sciences, 95: 581-588.
  3. McIntosh, M.P., Batey, A.J., Coker, S.J., Porter, C.J.H. and Charman, W.N. Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetised rabbit model. (2004) Journal of Pharmacy and Pharmacology, 56:69-77.
  4. McIntosh, M.P.,  Charman, W.N., Campbell, M. and Porter, C.J.H. Influence of physicochemical properties on the patterns of association of a series of aliphatic esters oh halofantrine with plasma lipoproteins. (2004) Journal of Controlled Release 95: 275-289.
  5. McIntosh, M.P., Schwarting, N. and Rajewski, R.A. in vitro and in vivo evaluation of a sulfobutyl ether ß-cyclodextrin enabled etomidate formulation. (2004) Journal of Pharmaceutical Sciences, 93: 2585-2594.
  6. McIntosh, M.P., Batey, A.J., Porter, C.J.H., Charman, W.N. and Coker, S.J. Desbutylhalofantrine: Evaluation of QT prolongation and other cardiovascular effects after intravenous administration in vivo. (2003) Journal of Cardiovascular Pharmacology, 41: 406-413.
  7. McIntosh, M.P. and Rajewski, R.A.  A simple and efficient high-performance liquid chromatographic assay for the quantitation of etomidate in plasma. (2001) Journal of Pharmaceutical and Biomedical Analysis, 24(4): 689-693.
  8. McIntosh, M.P., Porter, C.J.H., Wasan, K.M., Ramaswamy, M. and Charman, W.N. Differences in the lipoprotein binding profiles of halofantrine in fed and fasted human and beagle plasma are dictated by the respective masses of apolar lipid in the lipoprotein core. (1999) Journal of Pharmaceutical Sciences, 88(3): 378-384.
  9. Wasan, K.M., Ramaswamy, M., McIntosh, M.P., Porter, C.J.H. and Charman, W.N. Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein 1 activity: in vitro studies in normolipidemic and dyslipidemic human plasmas. (1999) Journal of Pharmaceutical Sciences, 88(2): 185-190.