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Richard J. Prankerd

Photo of Dr Prankerd

Senior Lecturer in Pharmaceutics

BPharm, MPharm, PhD, Univ. Otago

Phone: +61 3 9903 9003
Fax: +61 3 9903 9583
Email: Richard.Prankerd@pharm.monash.edu.au

General Research Interests

  • Physical and pharmaceutical chemistry
  • Solution equilibria and kinetics
  • Thermal analysis and spectroscopy
  • Analytical methods development
  • Formulation science

Current Research Areas

  • Applications of solution microcalorimetry in pharmaceutical and formulation science. (This work currently involves on-campus collaborations with Profs. W. Charman and C. Pouton, Assoc Profs. S. Charman and C. Porter, and Drs. M. Scanlon and D. Warren; off-campus collaborations with Dr. John Forsyth, Monash Clayton, and Dr Ross Kennedy, Charles Sturt Uni) 
  • Characterisation and pharmaceutical evaluation of a novel natural product gum. (Dr U.U. Ben-Nwauzor)
  • Development of novel gene transfection agents (collaboration with Prof. C. Pouton and Dr. J. Jazayeri)

Honours projects for 2008

Significant Publications

  1. Prankerd, R.J. Critical compilation of  PKA values for pharmaceutical substances. (2007) Profiles of drug substances, excipients, and related methodology 33.
  2. Horner, J., d'Auvergne, E.J., Coles, M., Velkov, T., Chin, Yanni., Charman, W.N., Prankerd, R., Gooley, P.R., Scanlon, M.J. Probing the flexibility of the DsbA oxidoreductase from vibrio cholerae -a 15N – 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA. (2007) Journal of Molecular Biology 371, 703-716.
  3. Creek, J.D., Charman, W.N., Chiu, F.C.K., Prankerd, R.J., McCullough, K.J., Dong, Y., Vennerstrom, J.L., Charman, S.A. Iron-mediated degredation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials. (2007) Journal of Pharmaceutical Sciences 96(11) 2945-2956.
  4. Perry, C., Charman, S.A., Prankerd, R.J., Chiu, F., Dong, Y., Vennerstrom, J. and Charman, W.N. Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials. (2006) Journal of Pharmaceutical Sciences 95(4): 373-747.
  5. Perry, C., Charman, S.A., Prankerd, R.J., Chiu, F., Scanlon, M., Chalmers, D. and Charman. W.N.  The binding interaction of synthetic ozonide antimalarials with natural and modified ß-cyclodextrins. (2006) Journal of Chromatography B 830: 314-321.
  6. Charman, S.A., Perry, C., Chiu, F., McIntosh, K.,  Prankerd, R.J., Charman, W.N.  Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. (2006) Journal of Pharmaceutical Sciences 95(2): 256-267.
  7. Velkov, T., Chuang, S., Prankerd, R., Sakellaris, H., Porter, C.J.H. and Scanlon, M. An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli. Protein Expression & Purification 44 23-31 (2005)
  8. Creek, D.J., Chiu, F., Prankerd, P., Charman, S.A. and Charman, W.N. Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt.   J. Pharm. Sci., 94: 1820-1829 (2005).
  9. Ben-Nwauzor, U.U. and Prankerd R.J., Isolation and studies on the chemical composition and structural characteristics of novel polysaccharide mucilage from the calyx of Bombax costatum. Carbohydrate Research, (2004).
  10. Davie, A.S., Campbell, M.,  Prankerd, R.J. and Charman, W.N. Stability of berenil in acidic aqueous solutions. J Pharm. Pharmacol. Vol. 56, No. 10 pp.1327-1332, (2004)
  11. Taillardat-Bertschinger, A., Perry,C.S., Galland, A.,  Prankerd, R.J. and Charman, W.N.  Partitioning of halofantrine hydrochloride between water, micellar solutions and soybean oil: Effects on its apparent ionization constant. J.Pharm.Sci. 92 (11) 2217-28, (2003)
  12. Khoo, S.M., Prankerd, R. J., Edwards,G. A., Porter, C.J.H. and  Charman, W. N.  A physicochemical basis for the significant intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after post-prandial administration. J.Pharm.Sci. 91, 647-659, (2003)
  13. Shackleford, D., Prankerd, R.J., Scanlon, M.J. and Charman, W.N. Self-micellization of Gemfibrozil 1-O-β Acyl Glucuronide in aqueous solution. Pharm. Res. 20(3) 465-470 2003.
  14. Prankerd, R.J. Stability Considerations in IV Drug Preparation and Use, in Manual of Home Parenteral Therapy, J. Neilson and G. Neilson, eds. 8 (2003).
  15. Prankerd, R.J. Aspartame, in Analytical Profiles of Drug Substances and Excipients, ed., H.G. Brittain (vol. 29, Academic Press, San Diego (2002) pp. 7-56).
  16. Preechagoon, D., Smith, M.T.S.and RJ Prankerd. Investigation of the antinociceptive efficacy and relative potency of long-acting injectable 3-acylmorphine-6-sulfate prodrugs in rats. Int J Pharm, 1998, 163, 191.
  17. Preechagoon, D., Brereton, I., Staatz, C. and Prankerd, R.J. 3-Acyl ester prodrugs of morphine-6-sulphate, a potent analgesic: syntheses, NMR spectra and some physico-chemical properties. Int J Pharm, 1998, 163, 177.
  18. Prankerd, R.J. and Elsabee, M. Thermal analysis of chiral drugs. The DSC behaviour of mixtures of ephedrine HCl and pseudoephedrine HCl enantiomers. Thermochimica Acta, 1995, 248, 147.
  19. Elsabee, M. and Prankerd, R.J. Solid state properties of drugs. Part III. Differential scanning calorimetry of drugs existing as racemic solid solutions, racemic mixtures and racemic compounds. Int J Pharm, 1992, 86, 221.
  20.  Prankerd, R.J., Stone, H.W., Sloan, K.B. and Perrin, J.H. Degradation of aspartame in acidic aqueous media and its stabilization by complexation with cyclodextrin or modified cyclodextrins. Int J Pharm, 1992, 88, 189.
  21. Prankerd, R.J. Solid state properties of drugs. Part I. Estimation of heat capacities for fusion and thermodynamic functions for solution from aqueous solubility-temperature dependence measurements. Int J Pharm, 1992, 84, 233.
  22. Prankerd, R.J. and McKeown, R.H. Physico-chemical properties of barbituric acid derivatives. Part I. Solubility-temperature dependence for 5,5-disubstituted barbituric acids in aqueous solutions. Int J Pharm, 1990, 62, 37.
  23. McKeown, R.H. and Prankerd, R.J. First thermodynamic dissociation constants of barbituric acids in water at 25°C. Part 3. 5,5-Alkylenebarbituric acids. A comparison with 5,5-dialkylbarbituric acids, and with mono- and di-carboxylic acids. J Chem Soc, (Perkin II), 1981, 481.