Department of Pharmaceutical Biology - Publications 2006-2007

Adams CL, Lawrence AJ (2007) CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Rev. 13(3):308-16. Review.

Adams CL, Cowen MS, Short JL, Lawrence AJ (2007) Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats. Int J Neuropsychopharmacol. 2008 Apr;11(2):229-41. Epub 2007 May 22.

Candenas Ml, Pennefather JN, Kerr K, Pérez-Hernández N, Pinto FM. (2007) Tachykinins and smooth muscle function. In: New Frontiers in Smooth Muscle Biology and Physiology: ISBN: 978-81-7895-295-6. Editor: Jean-Pierre Savineau, Research Signposts. Transworld Research Network 37/661 (2) Fort P.O. Trivandrum-695 023, Kerala India.

Chetty, N., Irving, H. R, Coupar, I. M (2007) Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract 2008;81(2):104-9. Epub 2007 Oct 19.

Chetty N., Coupar I.M., Chess-Williams R. and Kerr K.P. (2007) Demonstration of 5-HT3 receptor function and expression in the mouse bladder. Naunyn-Schmiedeberg's Arch Pharmacol. 375: 359-368.

Coupar, I. M, Desmond, P. V, Irving, H. R (2007) Human 5-HT4 and 5-HT7 splice variants: are they important? Current Neuropharmacology, Volume 5, Number 4, December 2007, pp.224-231.

Dworkin S., Heath J.K., deJong-Curtain TA., Hogan B.M., Lieschke G.J., Malaterre J., Ramsay R.G. and Mantamadiotis T. (2007) CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish. Developmental Biology 307: 127-141.

Gray, K. T, Short, J. L, Simpson, E. R, Ventura, S. (2007) The effects of targeted deletion of the aromatase enzyme on prostatic contractile responses to noradrenaline in mice. Journal of Endocrinology; 195: 495-502.

Haynes J.M. (2007) β₂ and β₃-adrenoceptor inhibition of α₁-adrenoceptor-stimulated Ca²⁺ elevation in human cultured prostatic stromal cells. European Journal of Pharmacology 570(1-3); 18-26.

Irving H., Tan Y.Y., Tochon-Danguy N., Liu H., Chetty N., Desmond P.V., Pouton C.W. and Coupar I.M. (2007) Comparison of 5-HT₄ and 5-HT₇ receptor expression and function in the circular muscle of the human colon. Life Sciences 80: 1198-1205.

Jazayeri J.A., De Weerd N., Raye W., Velkov T., Santos L., Taylor D., Carroll G.J. (2007) Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF. Journal of Immunological Methods, 323: 1-10.

Jazayeri J.A, De Weerd N., Raye W., Kivivouri S., Zabihi E. and Carroll G.J. (2007) In Vitro Evaluation of Leukaemia Inhibitory Factor Receptor Antagonists as Candidate Therapeutics for Inflammatory Arthritis. Journal of Interferon and Cytokine Research, Vol 27(4): 1-9.

Kopecki Z., Luchetti M.M., Adams D.H., Strudwick X., Mantamadiotis T., Stoppacciaro A., Gabrielli A., Ramsay R.G. and Cowin A.J. (2007) Collagen loss and impaired wound healing is associated with c-Myb deficiency. Journal of Pathology 211: 351-361.

Kwezi, L., Meier S., Mungur L., Ruzvidzo O., Irving H. and Gehring C. (2007) The Arabidopsis thaliana Brassinosteroid Receptor (AtBRI1) Contains a Domain that Functions as a Guanylyl Cyclase In Vitro. PLoS ONE. 2(5): e449. doi:10.1371/journal.pone.0000449, 2007.

Malaterre J., Mantamadiotis T., Dworkin S., Lightowler S., Nichols N.R., Ransome M.I., Turnley A.M., Emambokus N., Frampton J., Ramsay R.G. (2007) c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Stem Cells, Accepted Sep 18, 2007.

Malone, D. T, Kearn, C. S, Chongue, L., Mackie, K., Taylor, D. (2007) Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats. Neuroscience 152: 265-272.

Meier, S., Seoighe, C., Kwezi, L., Irving, H. R, Gehring, C. A (2007) Plant nucleotide cyclases: an increasingly complex and growing family. Plant Signaling and Behavior 2(6): 536-539.

Moseley G.W., Roth D.M., Dejesus M.A., Leyton D.L., Filmer R.P., Pouton C.W. and Jans D.A. (2007) Dynein Light Chain Association Sequences Can Facilitate Nuclear Protein Import, Mol Biol Cell 18(8): 3204-3213.

Nguyen D.-T., Lang R.J. and Exintaris B (2007) K+ channel modulation of slow wave activity in the guinea-pig prostate. British Journal of Pharmacology July; 151(6): 828–836. Published online 2007 May 29. doi: 10.1038/sj.bjp.0707283.

Nielsen S., Dietze P., Dunlop A, Muhleisen P, Lee N andTaylor D. (2007) Buprenorphine supply by community pharmacists in Victoria, Australia: perceptions, experiences and key issues identified. Drug and Alcohol Review 26: 143-151.

Nielsen S., Dietze P., Lee N., Dunlop A and Taylor D. (2007) Concurrent buprenorphine and benzodiazepines use and self-reported opioid toxicity in opioid substitution treatment. Addiction 102(4): 616-622(7).

Jocelyn N. Pennefather, Claire Garrett, Luba D. Tomaska, Elizabeth H. Brown (2007) Reproductive Pharmacology, in: Pharmacology, [Ed. Harry Majewski], in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford, UK [http://www.eolss.net]

Pouton C.W. and Haynes J.M. (2007) Embryonic stem cells as a source of models for drug discovery. Nature Rev Drug Discovery 2007 Aug;6(8):605-16.

Pouton C.W., Wagstaff K.M., Roth D.A., Moseley G.W. and Jans D.A. (2007) Targeting to the nucleus. Adv. Drug Deliv. Rev. 2007 Aug 10;59(8):698-717. Epub 2007 Jul 4.

Raye W.S., Tochon-Danguy N., Pouton C.W. and Haynes J.M. (2007) Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function. European Journal of Neuroscience 25: 1961-1970.

Roth D.M., Moseley G.W., Glover D., Pouton C.W. and Jans D.A. (2007) A Microtubule-Facilitated Nuclear Import Pathway for Cancer Regulatory Proteins. Traffic 8: 673-686.

Tokanovic S., Malone D.T. and Ventura S.(2007) Stimulation of epithelial CB₁ receptors inhibits contractions of the rat prostate gland. British Journal of Pharmacology 150: 227-234.

Wang Y.H., Gehring C.A, Cahill D.M, Irving H.R. (2007) Plant natriuretic peptide active site determination and effects on cGMP and cell volume regulation. Functional Plant Biology 34(7): 645-653.

Cao N., Haynes J.M. & Ventura S. (2006) Saw palmetto is an indirectly acting sympathomimetic in the rat isolated prostate gland. Prostate; 66: 115-123.

Cao N., Lau S., Nguyen T.T. and White P.J. (2006) Characterisation of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious Sprague Dawley rats. Clin. Exp. Pharm. Phys., 33: 1190-1195.

Chetty N., Irving H.R. and Coupar I.M. (2006) Activation of 5-HT₃ receptors in the rat and mouse intestinal tract: a comparative study. British Journal of Pharmacology 148: 1012-1021.

Cook A.M. & Haynes J.M. (2006) Phosphorylation of the PKG substrate, vasodilator-stimulated phosphoprotein (VASP), in human cultured prostatic stromal cells. Nitric Oxide Biology and Chemistry, in press (available online 2006).

Eppel G.A., Ventura S., Denton K.M. and Evans R.G. (2006) Lack of contribution of P2X receptors to neurally mediated vasoconstriction in the rabbit kidney in vivo. Acta Physiol 186:197.

Eppel G.A., Ventura S. and Evans R.G. (2006) Regional vascular responses to ATP and ATP analogues in the rabbit kidney in vivo: roles for adenosine receptors and prostanoids. British Journal of Pharmacology 149: 523-531.

Exintaris B., Nguyen D.T., Dey A. & Lang R.J. (2006) Spontaneous electrical activity in the prostate gland. Journal of Autonomic Neurosience: Basic and Clinical 126-127: 371-9.

Gray A.C., Coupar I.M. and White P.J. (2006) Comparison of opioid receptor distributions in the rat central nervous system. Life Sci. 79: 674-685.

Gray A.C., Coupar I.M. and White P.J. (2006) Comparison of opioid receptor distributions in the rat ileum. Life Sci. 78:1610-1616 (published online 2005).

Gray K.T. and Ventura S. (2006) a_1L-Adrenoceptors mediate contractions of the isolated mouse prostate. European Journal of Pharmacology 2006; 540: 155-161.

Haynes J.M. and Cook A.M. (2006) Protein kinase G-induced activation of K(ATP) channels reduces contractility of human prostate tissue. Prostate, 66(4):377-385.

Hsu B., Coupar I. and Ng K. (2006) Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica. Food Chemistry, 98: 317-328.

Iskander MN, Leung LM, Buley T, Ayad F, Di Iulio J, Tan YY, Coupar IM (2006) Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment. Eur J Med Chem. Jan; 41(1):16-26. Epub 2005 Nov 15.

Kelly-Skupek, M.N. and Irving, H.R. (2006) Pharmacological evidence for activation of phospholipid and cytoskeletal signalling cascades by Nod Factors. Plant Physiology and Biochemistry 44: 132-142, 2006.

Kerr K. (2006) The effect of histamine on field-stimulated contractions of the guinea-pig prostate. Naunyn-Schmiedeberg's Arch Pharmacol 373: 237-244.

Lang R.J., Nguyen D.T., Matsuyama H., Klemm M.F. (Dec.), Takewaki T. & Exintaris B. (2006) Characterization of the spontaneous depolarizations in the smooth muscle cells of the guinea-pig prostate Journal of Urology 175(1): 370-80.

Long L.E., Malone D.T. and Taylor D.A. (2006) Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice. Neuropsychopharmacology 2006 Apr;31(4):795-803 (published online 2005).

Malone D.T. and Taylor D.A. (2006) The effect of tetrahydrocannabinol on sensorimotor gating in socially isolated rats. Behav Brain Res. 2006 Jan 6;166(1):101-9.

Nguyen S.T., Prakash R., Anderson C.J., Frydenberg M. & Haynes J.M. (2006) Sex Steroids Modulate α₁-Adrenoceptor-Stimulated Ca²⁺ Elevation in Human Cultured Prostatic Stromal Cells. The Prostate, published online 2006.

Nguyen, T.T., Cao, N., Short, J.L. & White, P.J. (2006). Intravenous insulin-like growth factor-I receptor antisense treatment reduces angiotensin receptor expression and function in Spontaneously Hypertensive rats. J Pharmacol Exp Ther, 318, 1171-7.

Pennefather, Jocelyn N., Eva Patak, Sebastian Ziccone, Alison Lilley, Francisco M. Pinto, Nigel M. Page, Margot E. Story, Sonia Grover, and M. Luz Candenas (2006) Regulation of the Stimulant Actions of Neurokinin A and Human Hemokinin-1 on Human Uterus: a Comparison with Histamine. Biology of Reproduction, 75: 334-341. Published online ahead of print May 17, 2006.

Poole D.P. Xu, B., Koh S.L., Hunne B., Coupar I.M., Irving H.R., Shinjo K. and Furness J.B. (2006) Identification of neurons that express 5-hydroxytryptamine-4 receptors in the intestine. Cell and Tissue Research 325: 413-422, 2006.

Pouton C.W. (2006) Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. European Journal of Pharmaceutical Sciences 29: 278-287.

Short J.L., Drago J. & Lawrence A.J. (2006) Comparison of ethanol preference and neurochemical measures of mesolimbic dopamine and adenosine systems across different strains of mice. Alcohol Clin Exp Res, 30, 606-20.

Short J.L., Ledent C., Borrelli E., Drago J. & Lawrence A.J. (2006) Genetic interdependence of adenosine and dopamine receptors: Evidence from receptor knockout mice. Neuroscience, 139, 661-70.

Short J.L., Ledent C., Drago J. & Lawrence A.J. (2006). Receptor crosstalk: characterization of mice deficient in dopamine D₁ and adenosine A_2A receptors. Neuropsychopharmacology, 31, 525-34.

Smith A.I., Lew R.A., Thomas W. and Tochon-Danguy N. (2006) Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1. International Journal of Peptide Research & Therapeutics 12: 291-295.

Trevaskis N.L., Lo C.M., Ma L.Y., Tso P., Irving H.R., Porter C.J.H. and Charman W.N. (2006) An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats. Pharmaceutical Research (available online 21 July 2006 doi: 10.1007/s11095-006-9021-6).

Warren D.B., Chalmers D.K., Hutchison K., Dang W. and Pouton C.W. (2006) Molecular dynamics simulation of spontaneous bile salt aggregation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 280: 182.