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Colin W. Pouton

Photo of Prof Pouton

Professor of Pharmaceutical Biology

BPharm(Hons) University of Bath
PhD in Pharmaceutical Science University of London

Phone: +61 3 990 39562
Fax:     +61 3 990 39638
email: Colin.Pouton@pharm.monash.edu.au

General Research Interests

  • Drug design and lead optimisation
  • Drug absorption, Gene delivery, Protein transduction
  • Molecular pharmacology

Current Research Areas

  • Delivery of DNA to the cell nucleus by active transport
  • Attenuated bacteria for delivery of DNA vaccines
  • Membrane translocating peptides for delivery of macromolecular drugs
  • Molecular pharmacology of 5-HT and dopamine receptors
  • Use of differentiated stem cells in drug discovery

Significant Publications

  1. Pouton C.W. (2006) Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. European Journal of Pharmaceutical Sciences 29: 278-287.
  2. Martin F., Roth D.M., Jans D.A., Pouton C.W., Partridge L.J., Monk P.N. and Moseley G.W. (2005) Tetraspanins in viral infections: a fundamental role in viral biology? Journal of Virology 79, 10839-10851.
  3. Pouton C.W. and Allsopp T. (2005) Embryonic stem cell science and the therapeutic interface.  Advanced Drug Delivery Reviews, 57: 1891-1893.
  4. Pouton C.W. and Haynes J.M. (2005) Pharmaceutical applications of embryonic stem cells.  Advanced Drug Delivery Reviews 57: 1918-1934.
  5. Pouton C.W. and Seymour L.W. (2001) Key issues in non-viral gene delivery. Adv. Drug Delivery Rev. 46: 187-203
  6. Matthews S.E., Pouton C.W. and Threadgill M.D. (2001) Formation of hybrid polymethylene-poly(oxyethylene) macrocycles Tetrahedron Lett. 42: 1355-1357
  7. Garrett S.W., Davies O.R., Milroy D.A., Wood P.J., Pouton C.W. and Threadgill M.D. (2000) Synthesis and characterisation of polyamine-poly(ethylene glycol) constructs for DNA binding and gene delivery. Bioorganic & Medicinal Chemistry 8: 1779-1797
  8. Matthews S.E., Pouton C.W. and Threadgill M.D. (2000) A biodegradable multiblock co-polymer derived from an alpha,omega-bis(methylamino)peptide and an alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol). J. Controlled Release 67: 129-139
  9. Uduehi A.N., Moss S.H., Nuttall J. and Pouton C.W. (1999) Cationic lipid-mediated transfection of differentiated Caco-2 cells: A filter culture model of gene delivery to a polarized epithelium. Pharmaceut. Res. 16: 1805-1811
  10. Matthews S.E., Pouton C.W. and Threadgill M.D. (1999) Synthesis of porphyrin alpha,omega-bis(methylamino)peptide constructs. New J. Chem. 23: 1087-1096
  11. Sahm U.G. Olivier G.W.J. and Pouton C.W. (1999) Synthesis of 153N-6 analogues and structure-function analysis at murine melanocortin-1 (MC1) receptors. Peptides 20: 387-394
  12. Pouton C.W. and Seymour L.W. (1998) Key issues in non-viral gene delivery. Adv. Drug Delivery Rev. 34: 3-19
  13. Pouton C.W. (1998) Nuclear import of polypeptides, polynucleotides and supramolecular complexes. Adv. Drug Delivery Rev. 34: 51-64
  14. Pouton C.W., Lucas P., Thomas B.J., Uduehi A.N., Milroy D.A. and Moss S.H. (1998) Polycation-DNA complexes for gene delivery - a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J. Controlled Release. 53: 289-299
  15. Peng P.J., Sahm U.G., Doherty R.V.M., Kinsman R.G., Moss S.H. and Pouton C.W. (1997) Binding and biological activity of C-terminally modified melanocortin peptides - a comparison between their actions at rodent MC1 and MC3 receptors. Peptides 18: 1001-1008