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Daniel T. Malone

Photo of Dr Malone

Lecturer (level B)

BPharm(Hons) Monash University
PhD in Pharmacology Monash University

Phone: +61 3 990 39576
Fax:     +61 3 990 39638
email: Dan.Malone@pharm.monash.edu.au

General Research Interests

  • Neurochemical and behavioural effects of cannabinoids
  • Preclinical evaluation of novel antidepressant, anxiolytic and antipsychotic compounds
  • The disruption of sensorimotor gating as measured by prepulse inhibition
  • Environmental inducers of psychosis and schizophrenia-like symptoms

Current Research Areas

  • Evaluation of the effect of cannabinoids on sensorimotor gating
  • Investigation of the effects of cannabinoids on sensorimotor gating in animals with environmentally-induced psychosis
  • Role of neuromolecular markers such as Fos and CREB in psychosis and depression

Significant Publications

  1. Malone D.T., Kearn C.S., Chongue L., Mackie K. & Taylor D.A. (2008) Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats. Neuroscience 152: 265-272.
  2. Tokanovic S., Malone D.T. & Ventura S. (2007) Stimulation of epithelial CB1 receptors inhibits contractions of the rat prostate gland. British Journal of Pharmacology 150, 227-234.
  3. Malone D.T. and Taylor D.A. (2006) The effect of tetrahydrocannabinol on sensorimotor gating in socially isolated rats. Behav Brain Res. Jan 6;166 (1):101-9.
  4. Long L.E., Malone D.T. and Taylor D.A. (2006) Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice. Neuropsychopharmacology Apr;31 (4):795-803 (published online 2005).
  5. Long L.E. Malone D.T., and Taylor D.A. (2005) The pharmacological actions of cannabidiol. Drugs of the Future, 30 (7): 747-753.
  6. Malone D.T., Long L.E. & Taylor D.A. (2004) The effect of SR 141716 and apomorphine on sensorimotor gating in Swiss mice. Pharmacology, Biochemistry and Behavior 77/4: 839-845.
  7. Malone D.T. and Taylor D.A. (2001) Involvement of somatodendritic 5-HT1A receptors in Δ9-tetrahydrocannabinol-induced hypothermia in the rat. Pharmacol. Biochem. Behav. 69: 595-601.
  8. Malone D.T. and Taylor D.A. (1999) Modulation by fluoxetine of striatal dopamine release following Δ9-tetrahydrocannabinol: a microdialysis study in conscious rats. Br. J. Pharmacol. 128: 21-26.
  9. Malone D.T. and Taylor D.A. (1998) Modulation of Δ9-tetrahydrocannabinol-induced hypothermia by fluoxetine in the rat. Br. J. Pharmacol. 124: 1419-1424.