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Helen R. Irving

Photo of Dr Irving

Senior Lecturer

(faculty Biosafety Officer)

BAgSc(Hons) University of Melbourne
PhD in Biochemistry University of Melbourne
Grad Cert in Higher Education Monash University

Phone: +61 3 990 39565
Fax:     +61 3 990 39638
email: Helen.Irving@pharm.monash.edu.au

General Research Interests

  • Signal transduction mechanisms in plant and animal tissues
  • Molecular and functional distribution of receptors
  • Novel analogues of animal peptide hormones

Current Research Areas

  • Role of natriuretic peptide analogues in plants and their effect on animal tissues
  • Signal transduction mechanisms in plant symbiotic interactions
  • Distribution and function of 5-HT receptors
  • Opiates and opiate addiction

Significant Publications

  1. Chetty, N., Irving, H.R. and Coupar, I.M.  Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study.  British Journal of Pharmacolgy (available online 12 June 2006; doi:10.1038/sj.bjp.0706802)
  2. Trevaskis, N.L., Lo, C.M., Ma, L.Y., Tso, P., Irving, H.R., Porter, C.J.H. and Charman, W.N.    An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats.  Pharmaceutical Research (available online 21 July 2006 doi: 10.1007/s11095-006-9021-6)
  3. Poole, D.P. Xu, B., Koh, S.L., Hunne, B., Coupar, I.M., Irving, H.R., Shinjo, K. and Furness, J.B.    Identification of neurons that express 5-hydroxytryptamine-4 receptors in the intestine.  Cell and Tissue Research  325: 413-422, 2006.
  4. Kelly-Skupek, M.N. and Irving, H.R.  Pharmacological evidence for activation of phospholipid and cytoskeletal signalling cascades by Nod Factors.  Plant Physiology and Biochemistry  44: 132-142, 2006.
  5. Liu, H., Irving, H.R., Tan, Y.Y., Meng, L., Chetty, N. and Coupar, I.M.    The influences of gender and region on responses to 5-HT in the rat small intestine.  Pharmacology 72: 220-224, 2004.
  6. Maryani M.M., Morse M.V., Bradley G., Irving H.R., Cahill D.M. and Gehring C.A. In situ localisation associates biologically active plant natriuretic peptide immuno-analogues with conductive tissue and stomata. Journal of Experimental Botany 54: 1553-1564, 2003.
  7. Liu H., Coupar I.M. and Irving H.R. Effects of some antidepressant drugs on tryptaminergic response of the rat small intestine. Pharmacology 69: 88-92, 2003.
  8. Rafudeen S., Gxaba G., Makgoke G., Bradley G., Pironcheva G., Raitt L., Irving H. and Gehring C. A role for plant natriuretic peptide immuno-analogues in NaCl and drought stress responses. Physiologia Plantarum 119: 554-562, 2003.
  9. Gehring C.A. and Irving H.R. Natriuretic peptides - a class of heterologous molecules in plants. Molecules in focus. International Journal of Biochemistry & Cell Biology 35: 1318-1322, 2003.
  10. Kelly, M.N. and Irving, H.R. (2003) Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp. Planta 216: 674-685.
  11. Ludidi, N.N., Heazlewood, J.L., Seoighe, C.J, Irving, H.R. and Gehring, C.A. (2002) Expansin-like molecules: Novel functions derived from common domains. Journal of Molecular Evolution 54: 587-594.
  12. Liu H., Irving H.R. and Coupar I.M. (2001) Expression patterns of 5-HT7 receptor isoforms in the rat digestive tract. Life Sciences 69: 2467-2475.
  13. Kelly M.N. and Irving H.R. (2001) Nod factors stimulate plasma membrane delimited phospholipase C activity in vitro. Physiologia Plantarum 113: 461-468.
  14. Pharmawati M., Maryani M.M., Nikolakopoulos T., Gehring C.A. and Irving H.R. (2001) Cyclic GMP modulates stomatal opening induced by natriuretic peptides and immunoreactive analogues in Vicia faba. Plant Physiology and Biochemistry 39: 385-394.
  15. Darroch S.A., Irving H.R. and Mitchelson F.J. (2000) Characterisation of muscarinic receptor subtypes in avian smooth muscle. European Journal of Pharmacology 402: 161-169.
  16. Irving H.R., Boukli N.M., Kelly M.N. and Broughton W.J. (2000) Nod-factors in symbiotic development of root hairs. In "Root Hairs: Cell and Molecular Biology" (editors: R.W. Ridge and A.M. Emons) Berlin Springer-Verlag pp 241-265.
  17. Suwastika, I.N., Toop, T., Irving, H.R. and Gehring, C.A. (2000) In situ and in vitro binding of natriuretic peptide hormones in Tradescantia multiflora. Plant Biology 2: 1-3.