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Ian M. Coupar

Photo of Dr Coupar

Honorary Associate Professor

BPharm(Hons) University of London
PhD University of London

Phone: +61 3 990 39707
Fax:     +61 3 990 39638
email: Ian.Coupar@pharm.monash.edu.au

Research Interests

  • Opiate actions including addiction
  • Pharmacology of motility and fluid transport in the digestive tract
  • Pharmacology of 5-hydroxytryptamine (particularly of 5-HT3, 5-HT4 and 5-HT7 receptors),
    adenosine receptors and tachykinins
  • Functional methods in pharmacology
  • Medicinal chemistry and natural products


Significant Publications

  1. Irving HR, Tan YY, Tochon-Danguy N, Liu H, Chetty N, Desmond PV, Pouton CW, Coupar IM. (2007) Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life Sci. Mar 6;80(13):1198-205.
  2. Chetty N, Irving HR, Coupar IM. (2006) Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study. Br J Pharmacol. Aug;148(7):1012-21.
  3. Iskander MN, Leung LM, Buley T, Ayad F, Di Iulio J, Tan YY, Coupar IM. (2006) Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment. Eur J Med Chem. Jan;41(1):16-26.
  4. Gray AC, White PJ & Coupar IM (2005) Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum. Br J Pharmacol, advance online publication, January 24, 2005; 10.1038/sj.bjp.0706107.
  5. Liu H, Irving HR, Tan YY, Meng L, Chetty N & Coupar IM (2004) Influence of gender and region on responses to 5-HT in the rat small intestine.  Pharmacology, 72: 220-224.
  6. Liu H, Coupar IM & Irving HR (2003) Effects of some antidepressant drugs on tryptaminergic response of the rat small intestine. Pharmacology, 69: (2), 88-92.
  7. Coupar IM & Di Iulio JL (2003) The effects of tachykinins and 5-hydroxytryptamine on intestinal secretion. Clin. Exp. Pharmacol & Physiol., 30: 764-768.
  8. Iskander MN Song Y Coupar IM & Jiratchariyakul W (2002) Antiinflammatory screening of the medicinal plant Gynura procumbens. Plant Foods for Human Nutrition (in press)
  9. Coupar IM & Tran BLT (2002) Effects of adenosine agonists on consumptive behaviour and body temperature. J Pharm Pharmacol, 54: 289-294
  10. Liu H, Irving HR & Coupar IM (2001) Expression patterns of 5-HT7 receptor isoforms in the rat digestive tract. Life Sci, 69: 2467-2475
  11. Song Y Coupar IM & Iskander MN (2001) Structural prediction of antagonist affinity at the adenosine 2B receptor site using Molcular Field Analysis. Quant Struct-Act Relat, 20: 23-30
  12. Coupar IM & Tran BLT (2001) Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine. Life Sci, 69: 779 -790
  13. Hemedah M Coupar IM & Mitchelson FJ (2000) Characterisation of a 5-HT7 binding site in mouse ileum. Eur J Pharmacol, 387: 265-272
  14. Kerr KP Mitchelson F & Coupar IM (2000) Tachykinins play a minor role in mediating the third phase of thre contractile response to vagal nerve stimulation of the guinea-pig oesophagus. Neuropeptides, 34: 12-17
  15. Kerr KP Tran B & Coupar IM (2000) Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is medated by NK2 receptors. Br J Pharmacol, 131: 1461-1467
  16. Coupar IM (1999) Characterisation and tissue location of the neural adenosine receptor in the rat ileum. Br J Pharmacol, 126: 1269-1275

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