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Jalal A. Jazayeri

Photo of Dr Jazayeri

Lecturer (level B)

C.A. Chem. Eng. (Southampton Solent University)
M.Sc. Biol. Eng. & Biotechnology, (Birmingham University)
Ph.D. Molecular Biology, (University of Limerick)
Grad. Cert. Higher Education (Monash University)

Phone: +61 3 9903 9653
Fax:     +61 3 9903 9638
email: jalal.jazayeri@pharm.monash.edu.au

General Research Interests

  • Molecular approaches to therapeutic drug development
  • Transcriptional regulatory processes
  • Expression patterns of epidermal growth factor and other receptors in cancer cells
  • Roles of cytokines, growth factors and their receptors in disease development

Current Research Areas

  • Cytokines as therapeutic agents for inflammatory arthritis
  • Rational design of non-viral gene delivery systems using new chemical entities
  • Attenuated bacteria for delivery of DNA vaccines
  • Investigating possible involvement of mutations in HFE genes and progression of osteoarthritis

Recent Publications

  1. Tarwadi, Jalal A. Jazayeri, Richard J. Prankerd and Colin W. Pouton (2008)  Preparation and in Vitro Evaluation of Novel Lipopeptide Transfection Agents for Efficient Gene Delivery. Bioconjugate Chemistry (accepted).
  2. Jazayeri J.A. and Carroll G.J. (2008) Fc-based cytokines – prospects for engineering superior therapeutics, Biodrugs 22(1)11-26.
  3. Jazayeri J.A., De Weerd N., Raye W., Velkov T., Santos L., Taylor D., Carroll G.J. (2007) Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF, Journal of Immunological Methods, 323: 1-10.
  4. Jazayeri J.A, De Weerd N., Raye W., Kivivouri S., Zabihi E. and Carroll G.J. (2007) In Vitro Evaluation of Leukaemia Inhibitory Factor Receptor Antagonists as Candidate Therapeutics for Inflammatory Arthritis.  Journal of Interferon and Cytokine Research., Vol 27(4): 1-9.
  5. Jazayeri J. (2004) Biochemical studies on sheep body louse Bovicola ovis (Schrank) (Phthiraptera: Trichodectidae): comparison of pyrethroid and organophosphate resistant and susceptible strains, Pesticide Biochemistry and Physiology Vol 80/1 pp 1-11.
  6. Giles, K.M., Daly, J.M., Beveridge, D. J., Thomson, A.M. Jazayeri, J. A. and Leedman, P.J. (2003). The 3'-UTR of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein (CP1) Journal of Biological Chemistry 278, 5, 2937-2946.
  7. Balmer L.A., Beverage D.J., Jazayeri J.A., Holmes E.M., Thomos A.M., Walker C.E. and Leedman P.J. (2001) Identification of a novel AU-rich element in the 3'-untranslated region of EGF-receptor mRNA that is the target for regulated RNA-binding proteins. Molecular and Cellular Biology 21: 2070-2084.
  8. Seth D., Shaw K., Jazayeri J.A. and Leedman P.J. (1999) Complex transcriptional and post-transcriptional regulation of EGF-receptor expression by EGF and TGF in human prostate cancer cells. British Journal of Cancer  80: 657-669.
  9. McCulloch R.K., Walker C.E., Chakera A., Jazayeri J.A. and Leedman P.J. (1998) Regulation of EGF-receptor expression by EGF and TGF in epidermoid cancer cells is cell-type specific. The International J.of Biochem. and Cell Biology 30: 1265-1278.
  10. Yang HA, Sivasithamparam K, Jazayeri JA, Barton JE and O’Brien PA (1993).  Association of Rhizoctonia strains with bare patch disease of wheat in Western Australia.  Plant Pathology Vol 43 p 878-884.
  11. Jazayeri JA  and Pembroke J.T.  (1990). Transformation of the coryneform bacterium Cellulomonas flavigena with plasmid DNA via Electroporation.   Biotechnology Techniques 4(2):147-148.
  12. Pembroke J.T. and Jazayeri JA  (1989). High frequency transformation of Cellulomonas flavigena using a shuttle vector derived from E.coli and Brevibacterium lactofermentum.  ASM Biotechnology 1:238.
  13. Jazayeri JA  and Pembroke J.T.  (1989). Mutants of Cellulomonas flavigena with altered cell-associated amylase activity.  Biotechnology Letters 11(1):75.
  14. Pembroke, J.T., Jazayeri JA. and J.F.McCarthy  (1986). Studies on the amylase activity of Cellulomonas flavigena.  Microbe Vol 86 143-145.