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Jocelyn N. Pennefather

Honorary Associate Professor

BSc University of Sydney
MSc University of Sydney
PhD in Pharmacology University of Sydney

Phone: +61 3 990 39563
Fax:     +61 3 990 39638
email: Jocelyn.ONeil@pharm.monash.edu.au

General Research Interests

  • Smooth muscle pharmacology
  • Operational studies of G-protein coupled receptors in uterine and bladder smooth muscle

Current Research Areas

  • Neuronal and non-neuronal tachykinins
  • Oestrogen regulation of G-protein coupled receptors in bladder and uterine smooth muscle

Significant Publications

  1. Pennefather, Jocelyn N., Eva Patak, Sebastian Ziccone, Alison Lilley, Francisco M. Pinto, Nigel M. Page, Margot E. Story, Sonia Grover, and M. Luz Candenas (2006) Regulation of the Stimulant Actions of Neurokinin A and Human Hemokinin-1 on Human Uterus: a Comparison with Histamine. Biology of Reproduction, 75: 334-341.  Published online ahead of print May 17.
  2. Candenas L., Lecci A., Pinto F.M., Patak E., Maggi C.A. and Pennefather J.N. (2005) Tachykinins and tachykinin receptors: effects in the genitourinary tract.  Life Sciences, 76, 835-862
  3. Patak E., Pinto F.M., Story M.E., Pintado C.O. Fleming A., Page N.M., Pennefather J.N. Candenas M.Luz. (2005) Functional and molecular characterization of tachykinins and tachykinin receptors in the mouse uterus. Biology of Reproduction, 72: 1125-1133.
  4. Pennefather J. N., Lecci A., Candenas M. L., Patak E., Pinto F. M., Maggi C. A. (2004). Tachykinins and tachykinin receptors: a growing family. Life Sci. 74, 1445-1463. (invited review).
  5. Ma S., Story M.E., Pennefather J.N. (2004) Muscarinic receptors mediating contraction of female mouse urinary bladder: effects of oestrogen. Eur. J. Pharmacol. 487, 205-211
  6. Patak E., Candenas M.L., Pennefather J N., Ziccone S., Lilley A., Martín J. D, Flores C., Mantecón A.G., Story M. E., Pinto F. M. (2003) Tachykinins and tachykinin receptors in human uterus Br. J. Pharmacol. 139, 523-544
  7. Pintado C.O., Pinto F.M., Pennefather J.N., Hidalgo A., Baamonde A., Sanchez,T. & Candenas M.L. (2003). A role for tachykinins in female mouse and rat reproductive function. Biol Reprod. 69, 940-946.
  8. Patak E., Pennefather,J.N., Fleming, A., Story M.E. (2002) Functional characterisation of tachykinin NK1 receptors in the mouse uterus. Br. J. Pharmacol. 137, 1247-54.
  9. Candenas M., Cintado C.G., Pennefather J.N., Pereda M.T, Loizaga J.M, Maggi C.A., Pinto F.M. (2002) Identification of a tachykinin NK2 receptor splice variant and its expression in human and rat tissues, Life Sci. 72, 269-277.
  10. Ventura S., Pennefather J.N. & Mitchelson F. (2002) Cholinergic innervation and function in the prostate gland. Pharmacol. Ther. 94, 93-112 (invited review)
  11. Patak E.N., Ziccone S., Story M.E., Fleming A.J., Lilley A. and Pennefather J.N. (2000) Activation of neurokinin NK2 receptors by tachykinin peptides causes contraction of uterus in pregnant women near term. Mol. Human Reprod. 6: 549-554
  12. Pennefather J.N., Lau W.A.K., Mitchelson F.J. and Ventura S. (2000) The autonomic and sensory innervation of the smooth muscle of the prostate gland. J. Auton. Pharmacol. 20: 193-206
  13. Lau W.A.K, Pennefather J.N. and Mitchelson F.J. (2000) Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea-pig prostate gland. Br. J. Pharmacol. 130: 1013-1020
  14. Lau W.A.K, Cox S. Pennefather J.N. and Mitchelson F.J. (1999) Characterisation of endothelin receptor subtypes in the guinea-pig prostate gland. Br. J. Pharmacol. 127: 1091-1098
  15. Fisher L. and Pennefather J.N. (1998) Structure-activity studies of analogues of neurokinin A mediating contraction of rat uterus. Neuropeptides 32: 405-410

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