Skip to content | Change text size
 

Paul J. White

Senior Lecturer

BSc Monash University
PhD in Pharmacology Monash University
Grad Cert in Higher Education Monash University

Phone: +61 3 990 39074
Fax:     +61 3 990 39638
email: Paul.White@pharm.monash.edu.au

Current Research Areas

  • Antisense and RNAi in vivo
  • Cardiovascular role of IGF-I
  • Development of new antisense therapeutic agents (Consultant to Antisense Therapeutics Ltd)
  • Interaction of adenosine receptors with caffeine and opiates

Honours projects for 2008

Significant Publications

  1. T.T Nguyen, N. Cao, J.L. Short and P.J. White. Intravenous IGF-I receptor antisense treatment reduces angiotensin receptor expression and function in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther., in press.
  2. N. Cao, S. Lau, T.T. Nguyen and P.J. White. Characterisation of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious Sprague Dawley rats. Clin. Exp. Pharm. Phys., 33: 1190-1195.
  3. Gray A.C., Coupar I.M., White P.J.  Comparison of opioid receptor distributions in the rat central nervous system. Life Sci., 79:674-685.
  4. Gray A.C., Coupar I.M., White P.J. (2006) Comparison of opioid receptor distributions in the rat ileum. Life Sci.; 78:1610-1616.
  5. Nguyen T.T., White P.J. (2005) Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats. Br J Pharmacol.; 146:935-941.
  6. Gray A.C., White P.J., Coupar I.M. (2005) Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum. Br J Pharmacol. Mar; 144(5):687-94.
  7. White P.J., Atley L.M., Wraight C.J. (2004) Antisense oligonucleotide treatments for psoriasis. Expert Opin Biol Ther. Jan;4(1):75-81. Review.
  8. White P.J., Nguyen T.T. (2002)  Chronic caffeine treatment causes changes in cardiac adenosine receptor function in rats. Pharmacology. Jul;65(3):129-35.
  9. White P.J., Gray A.C., Fogarty R.D., Sinclair R.D., Thumiger S.P., Werther G.A., Wraight C.J.  (2002) C-5 propyne-modified oligonucleotides penetrate the epidermis in psoriatic and not normal human skin after topical application. J Invest Dermatol.  Jun;118(6):1003-7.
  10. Fogarty R.D., McKean S.C., White P.J., Atley L.M., Werther G.A., Wraight C.J.  (2002) Sequence dependence of C5-propynyl-dU,dC-phosphorothioate oligonucleotide inhibition of the human IGF-I receptor: mRNA, protein, and cell growth. Antisense Nucleic Acid Drug Dev. Dec;12(6):369-77. 
  11. Wraight C.J. and White P.J. (2001) Antisense therapy for the skin. Pharmacology and Therapeutics in press (invited review article).
  12. Wraight C.J., White P.J., Fogarty R.D., McKean S.C., Venables D.J. and Werther G.A. (2000) Reversal of epidermal thickening in psoriasis by antisense oligonucleotides to the insulin-like growth factor Type I receptor. Nature Biotechnology 18: 521-526.
  13. White P.J., Fogarty R.D., Werther G.A. and Wraight C.J. (2000) Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: a model for antisense strategies in keratinocytes. Antisense & Nucleic Acid Drug Development 10: 195-203.
  14. White P.J., Fogarty R.D., McKean S.C., Venables D.J., Werther G.A. and Wraight C.J. (1999) Oligonucleotide uptake in cultured keratinocytes: influence of confluence, cationic liposomes and cell type. J. Invest. Dermatol. 112: 699-705.
  15. White P.J., Fogarty R.D., Liepe I.J., Delaney P.M., Werther G.A. and Wraight C.J. (1999) Live confocal microscopy of oligonucleotide uptake by keratinocytes in human skin grafts on nude mice. J. Invest. Dermatol. 112: 887-892.