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Theo Mantamadiotis

Senior Lecturer

BAppSc RMIT
BSc(Hons) Monash University
PhD University of Melbourne

Phone: +61 3 990 39574
Fax:     +61 3 990 39638
Email:   theo.mantamadiotis@pharm.monash.edu.au

General Research Interests

  • Regulation of gene expression
  • Stem and progenitor cell proliferation and differentiation
  • Interaction between transcription factors
  • Molecular genetic approaches to study disease

Current Research Interests

  • The role of the cAMP Response Element Binding (CREB) protein in cell function
  • Neural stem and progenitor cell proliferation and differentiation
  • Delineation of transcriptional networks in stem and progenitor cells

Significant Publications

  1. Huynh D, Vincan E, Mantamadiotis T, Purcell D, Chan C-K, Ramsay RG (2007) Oncogenic properties of HIV-Tat in colorectal cancer cells. Current HIV Research, 5: 403-409.
  2. Malaterre J., Ramsay R.G. and MantamadiotisT. Wnt-frizzled signaling and the many paths to neural development and adult brain homeostasis. Frontiers in Bioscience, (In Press) (2006).
  3. MantamadiotisT., Kretz O., Ridder S., Bleckmann S.C., Bock D., Gröne H.-J., Malaterre J., Dworkin S., Ramsay R.G., Schütz G. Hypothalamic CREB loss causes anterior pituitary hypoplasia and dwarfism in mice. Molecular Endocrinology 20(1):204-211 (2006)
  4. Ramsay R.G., Ciznadija D., Sicurella C., Reyes N., Mitchelhill K., Darcy P.K., D’Abaco G., Mantamadiotis T. Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS. DNA Cell Biol., 24(1):21-29 (2005)
  5. Baumann S., Kyewski B., Bleckmann S.C., Greiner E., Rudolph D., Schmid W., Ramsay R.G., Krammer P.H., Schütz G., Mantamadiotis T.CREB function is required for normal thymic cellularity and post-irradiation recovery. European Journal of Immunology, 34:1961-1971 (2004)
  6. Ramsay R.G., Micallef S., Lightowler S., Mucenski M.L., Mantamadiotis T., Bertoncello  I. c-myb Heterozygous mice are hypersensitive to 5-Fluorouracil and Ionizing Radiation. Mol. Cancer Res. 2(6):354-361 (2004)
  7. Ramsay R.G., Micallef S., Williams B., Lightowler S., Vincan E., Heath J.K., Mantamadiotis T., and Bertoncello I. Colony-Stimulating Factor 1 Promotes Clonogenic Growth of Normal Murine Colonic Crypt Epithelial Cells in vitro. J. Interferon and Cytokine Research, 24(7):416 (2004).
  8. Valverde O., Mantamadiotis T., Torrecilla M., Ugedo L., Pineda J., Bleckmann S., Gass P., Kretz O., Mitchell J.M., Maldonado R. and Schütz G. Modulation of Anxiety-Like Behavior and Morphine Dependence in CREB Deficient Mice. Neuropsychopharmacology, 29(6):1122-33(2004)
  9. Ramsay R.G., Ciznadija D., Vanevski M., Mantamadiotis T. Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. Int. J. Immunopath. Pharmacol. 16(2 suppl.):59-67 (2003)
  10. Balschun D., Wolfer D.P., Gass P., Mantamadiotis T., Welzl H., Schütz G., Frey,J.U. and Lipp H.-P. Does CREB Have a Pivotal Role in Hippocampal Synaptic Plasticity and Hippocampus-Dependent Memory? J.Neurosci. 23(15):6304-6314 (2003)
  11. Casanova E., Fehsenfeld S., Lemberger T., Shimshek D.R., Sprengel R., Mantamadiotis T. ER-based Double iCre Fusion Protein Allows Partial Recombination in Forebrain. Genesis 34(3):208-214 (2002)
  12. Mantamadiotis T., Lemberger T., Bleckmann SC., Kern H., Kretz O., Martin-Villalba A., Tronche F., Kellendonk C, Gau D., Kapfhammer J., Otto C., Schmid W., Schütz G. Disruption of CREB function in brain leads to neurodegeneration. Nature Genetics 31(1):47-54 (2002)
  13. Taraviras S.,Mantamadiotis T., Dong-Si T., Mincheva A., Lichter P., Drewes T., Ryffel GU., Monaghan AP., Schütz G. Primary structure, chromosomal mapping, expression and transcriptional activity of the murine Hepatocyte Nuclear Factor 4g (mHNF4g) gene. Biochim. Biophys. Acta – Gene Struct Expression 1490:21-32 (2000)  
  14. Mantamadiotis T., Taraviras S., Tronche F., Schütz G. PCR-based strategy for genotyping mice and ES cells harboring loxP sites. Biotechniques 25: 968-972 (1998)
  15. Mantamadiotis T., Baldwin GS. The seventh transmembrane domain of gastrin/CCK receptors contributes to non-peptide antagonist binding. Biochem. Biophys. Res. Commun., 201: 1382-1389 (1994)
  16. Mantamadiotis T.,  Sobieszczuk P.,  Weinstock J., Baldwin GS. Nucleotide sequence encoding a novel member of the hydratase/dehydrogenase family. Biochim. Biophys. Acta - Mol Cell Biol Lipids, 1170: 211-215 (1993)

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