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Jian Li

NHMRC R. Douglas Wright Research Fellow

Senior Research Scientist, Facility for Anti-Infective Drug Development and Innovation (FADDI)

B.Sc. in microbiology, Shandong University
M.Sc. in microbiology, Shandong University
Ph.D. in pharmaceutical science and microbiology, University of South Australia

Phone: +61 3 9903 9702
Fax: +61 3 9903 9629
E-mail: Jian.Li@pharm.monash.edu.au

Research Interests

  • Pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins
  • Mechanism of polymyxin resistance in Pseudomonas aeruginosa and Acinetobacter baumannii
  • Novel combinations of antimicrobial agents
  • Novel anti-pathogenic agents
  • Antimicrobial chemotherapy for infections in patients with cystic fibrosis
  • Integration of pharmacokinetic (PK) and pharmacodynamic (PD) to assist in antimicrobial development, to reduce resistance development and to optimize efficacy in the clinical use of antimicrobial agents
  • Discovery of novel antimicrobial agents
  • Lead optimisation of new antimicrobial entities

Honours, Masters and Phd Projects for 2008

Current Professional Memberships

  • Member of the International Society of anti-infective Pharmacology
  • Member of the Australian Society for Antimicrobials
  • Member of the American Society for Microbiology
  • Member of the Australasian Pharmaceutical Science Association

Grants

  • NHMRC Project Grant 384194; 2006-2008
    New therapy for Gram-negative superbugs
    Chief Investigators: J Li, RL Nation, CR Rayner, J Turnidge
  • NHMRC Project Grant 284265; 2004-2006
    Chief Investigator: RL Nation, J Li, J Turnidge, K Coulthard, R Milne, CR Rayner Associate Investigator: J Martin
    Towards optimising dosing of the ‘old’ antibiotic colistin methanesulphonate: enhancing efficacy and reducing resistance

Selected Peer Reviewed Papers

  1. Zavascki, A.P., Goldani, L.Z., Li, J., Nation, R.L.  Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. Journal of Antimicrobial Chemotherapy. 2007, in press.
  2. Tan, C-H., Li, J. and Nation R.L.  Colistin against Acinetobacter baumannii in an in vitro Pharmacokinetic/Pharmacodynamic model: antibacterial activity and emergence of resistance.  Antimicrobial Agents and Chemotherapy, 2007, 51(9):3413-3415.
  3. Li, J., Nation, R.L., Owen, R.J., Wong, S., Spelman, D. and Franklin, C.  Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of colistin-resistant strains.  Clinical Infectious Diseases, 2007, 45(5):594-598.
  4. Boak, L.M., Li, J., Rayner, C.R. and Nation, R.L.  Pharmacokinetic/pharmacodynamic factors influencing emergence of resistance to linezolid in an in vitro model.  Antimicrobial Agents and Chemotherapy.  2007, 51(4):1287-1292.
  5. Sudhakaran, S., Rayner, C.R., Li, J., Kong, D.C.M., Gude, N.M. and Nation, R.L.  Differential protein binding of indinavir and saquinavir in matched maternal and umbilical cord plasma.  British Journal of Clinical Pharmacology,  2007, 63(3):315-321.
  6. Li, J., Nation, R.L., Turnidge, J.D., Milne, R.W., Coulthard, K., Rayner, C.R. and Paterson, D.L. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. The Lancet Infectious Diseases. 2006, 6:589-601.
  7. Li, J., Rayner, C.R., Nation, R.L., Owen, R.J., Spelman, D., Tan, K.E. and Liolios L. Hetero-resistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. 2006, 50(9):2946-2950.
  8. Li, J., Nation, R.L. and Turnidge, J.D.  Defining the dosage units for colistin methanesulfonate: the urgent need for international harmonisation.  Antimicrobial Agents and Chemotherapy. 2006, 50(12):4231-4232.
  9. Bergen, P.J., Li, J., Rayner, C.R. and Nation, R.L. Colistin methanesulfonate is an inactive pro-drug of colistin against Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2006, 50(6):1953-1958.
  10. Boak, L.M., Li, J., Spelman, D., Nation, R.L. and Rayner, C.R. Successful treatment and cerebrospinal fluid penetration of oral linezolid in a patient with coagulase-negative staphylococcus ventriculitis. Annals of Pharmacotherapy. 2006, in press.
  11. Li, J., Nation, R.L., Turnidge, J.D., Milne, R.W., and Coulthard, K. Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria. International Journal of Antimicrobial Agents, 2005, 25:11-26. 
  12. Li, J., Nation, R.L., Milne, R.W., Turnidge, J.D., Smeaton, T.C., and Coulthard, K. Pharmacokinetics of colistin methanesulphonate and colistin in a critically ill patient receiving continuous venovenous hemodiafiltration. Antimicrobial Agents and Chemotherapy. 2005, 49(11):4814-4815.
  13. Li, J., Nation, R.L., Milne, R.W., Turnidge, J.D., Smeaton, T.C., and Coulthard, K. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. Journal of Antimicrobial Chemotherapy. 2004, 53:837-840.
  14. Li, J., Coulthard, K., Milne, R.W., Nation, R.L., Conway, S., Peckham, D., Etherington, C., and Turnidge, J.D. Steady-state pharmacokinetics of intravenous colistin methanesulpho-nate in patients with cystic fibrosis. Journal of Antimicrobial Chemotherapy. 2003, 52(6): 987-992.
  15. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Smeaton, T.C., and Coulthard, K. Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration. Antimicrobial Agents and Chemotherapy. 2003, 47(5): 1766-1770.
  16. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., and Coulthard, K. Stability of colistin and colistin methanesulfonate in aqueous media and plasma studied by High-performance Liquid Chromatography. Antimicrobial Agents and Chemotherapy. 2003, 47(4): 1364-1370.
  17. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Coulthard, K. and Valentin J. Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography. Antimicrobial Agents and Chemotherapy. 2002, 46(10): 3304-3307.
  18. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Coulthard, K. and Johnson, D.W. A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reverse phase high-performance liquid chromatography. Journal of Chromatography B, Biomedical Sciences and Applications. 2001, 761(2):167-175.
  19. Li, J., Turnidge, J.D., Milne, R.W., Nation, R.L. and Coulthard, K. In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrobial Agents and Chemotherapy. 2001, 45(3):781-785.
  20. Li, Y.Z., Li, J., Zhou, L., Zhang, Y., Hu, W., and Chen, Q. Isolation and identification of the myxobateria sources in China. Acta Microbiologica Sinica. 2000, 40(6):652-656.
  21. Li, J., Guo, X.Z., Li, Y.Z. and Zhou, L. Primary study on antitumor metabolites produced by a myxobacterium Corallococcus coralloides 9736. Chinese Journal of Antibiotics. 1999, 24(4):308-309.