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Roger L Nation

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Professor and Head of Department of Pharmacy Practice

Director, Facility for Anti-infective Drug Development and Innovation (FADDI)

PhC (Tasmania); MSc (University of Sydney); PhD (University of Sydney).

Phone: +61 3 9903 9061
Fax: +61 3 9903 9629
e-mail: Roger.Nation@pharm.monash.edu.au

Research Interests

  • Pharmacokinetics and pharmacodynamics, particularly in relation to anti-infective drugs
  • Optimisation of use of anti-infective drugs
  • Hepatic and renal handling of drugs and metabolites
  • In vitro and other models to investigate pharmacokinetics and pharmacodynamics of anti-infective and other drugs
  • Transport of drugs and metabolites across biological membranes
  • Medication and patient safety
  • Development of new areas of professional pharmacy practice

Honours, Masters and PhD projects for 2008

Selected Recent Publications

  1. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Smeaton, T.C. and Coulthard, K. Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate. Journal of Antimicrobial Chemotherapy 53:837 – 840 (2004)
  2. Evans, A.M., Faull, R.J., Nation, R.L., Prasad, S., Elias, T., Reuter, S.E. and Fornasini, G. Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. Kidney International 66: 1527 – 1534 (2004)
  3. Li, J., Rayner, C and Nation, R.L. Simple method for the assay of eperozolid in Brain Heart Infusion broth by high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 35: 847 – 851 (2004)
  4. Wang, J., Nation, R.L., Evans, A.M. and Cox, S. Renal excretion mechanisms of the antiviral nucleoside analogue AM188 in the rat isolated perfused kidney. Clinical and Experimental Pharmacology and Physiology 31: 29 – 34 (2004)
  5. Shackleford, D.M., Nation, R.L., Milne, R.W., Hayball, P.J. and Evans, A.M. Stereoselective hepatic disposition of model diastereomeric acyl glucuronides. Journal of Pharmacokinetics and Pharmacodynamics 31: 1 – 27 (2004)
  6. Wang, J., Nation, R.L., Evans, A.M. and Cox, S. Renal excretion mechanisms of the antiviral nucleoside analogue AM188 in the rat isolated perfused kidney. Clinical and Experimental Pharmacology and Physiology 31: 29 – 34 (2004)
  7. Wang, J., Nation, R.L., Evans, A.M. and Cox, S. Isolated rat kidney perfused with dextran and bovine serum albumin: A stable model for investigating renal drug handling. Journal of Pharmacological and Toxicological Methods 49: 105 – 113 (2004)
  8. Li, J., Rayner, C., Dixson, S. and Nation, R.L. Simple method for the assay of linezolid in brain heart infusion broth by high performance liquid chromatography. Biomedical Chromatography 18: 1 – 5 (2004)
  9. Nation, R.L. and Rayner, C. Clinical Pharmacokinetics. A Textbook of Clinical Pharmacy Practice – Essential Concepts and Skills. Editors G Parthasarathi, K Nyfort-Hansen and M.C Nahata, Orient Longman, Hyderabad, India (2004).
  10. Li, J., Coulthard, K., Milne, R.W., Nation, R.L., Conway, S., Peckham, D., Etherington, C. and Turnidge, J.D. Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis. Journal of Antimicrobial Chemotherapy 52: 987 – 992 (2003)
  11. Karpf, D.M., Kirkegaard, A.L., Evans, A.M., Nation, R.L., Hayball, P.J. and Milne, R.W. Effect of ketoprofen and its enantiomers on the renal disposition of methotrexate in the isolated perfused rat kidney. Journal of Pharmacy and Pharmacology 55: 1641 – 1646 (2003)
  12. Lucas, A.N., Brogen, L.R., Nation, R.L., Milne, R.W., Evans, A.M. and Shackleford, D.M. The effects of the phytoestrogenic isoflavone genistein on the hepatic disposition of preformed and hepatically-generated gemfibrozil 1-O-acyl glucuronide in the isolated perfused rat liver. Journal of Pharmacy and Pharmacology 55: 1433 - 1439 (2003)
  13. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Smeaton, T.C. and Coulthard, K. Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration. Antimicrobial Agents and Chemotherapy 47: 1766 - 1770 (2003)
  14. Lucas, A.N., Nation, R.L., Milne, R.W., Reynolds, G.D. and Evans, A.M. The effects of phyoestrogenic isoflavones on the formation and disposition of paracetamol sulfate in the isolated perfused rat liver. Journal of Pharmacy and Pharmacology 55: 639 – 646 (2003)
  15. Gunawardana, D.H., Basser, R.L., Davis, I.D., Cebon, J., Mitchell, P., Underhill, C., Kilpatrick, T.J., Reardon, K., Green, M.D., Bardy, P., Amor, P., Crump, D., Nation, R.L. and Begley C.G. A Phase I studey of recombinant human leukaemia inhibitory factor in patients with advanced cancer. Clinical Cancer Research 9: 2056 – 2065 (2003)
  16. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Coulthard, K. Stability of colistin and colistin methanesulfonate in aqueous media and plasma as determined by high-performance liquid chromatography. Antimicrobial Agents and Chemotherapy 47: 1364 - 1370 (2003)
  17. Marriott, J.L. and Nation, R.L. Splitting tablets. Australian Prescriber 25: 133-135 (2002)
  18. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Coulthard, K. and Valentine, J. Simple method assaying of colistin methanesulfonate in plasma and urine using high-performance liquid chromatography. Antimicrobial Agents and Chemotherapy 46: 3304 – 3307 (2002).
  19. Hotham, N. and Nation, R.L. Medicines and breastfeeding. Australian Pharmaceutical Formulary and Handbook, 18th Edition, Editor L.N. Sansom (2002).
  20. Nation, R.L., Cheek, J., Gilbert, A., Ballantyne, A., Cosh, D., Barnes, L. and Paradiso, L. Modification of oral formulations. Australian Pharmaceutical Formulary and Handbook, 18th Edition, Editor L.N. Sansom (2002).
  21. Nation, R.L. Medicines and older people. Australian Pharmaceutical Formulary and Handbook, 18th Edition, Editor L.N. Sansom (2002).
  22. Paradiso, L.M., Roughead, E.E., Gilbert, A.L., Cosh, D., Nation, R.L., Barnes, L., Cheek, J. and Ballantyne, A. Crushing or altering medications: What’s happening in residential aged-care facilities? Australasian Journal on Ageing 21: 123 – 127 (2002)
  23. Strindelius, L.C., Nation, R.L., Evans, A.M., Cabot, J.L. and Corbett, K.M. Effect of oraganic cations on the renal tubular secretion of pseudoephedrine in the rat. Clinical and Experimental Pharmacology and Physiology 28: 43 – 47 (2001).
  24. Rosenthal, M.A., Kavar, B., Hill, J.S., Morgan, D.J., Nation, R.L., Daniel, M., Varigos, G., Searle, M., Stylli, S.S., Uren, S., Geldard, H., Green, M.D., Basser, R.L., Kahl, S.B. and Kaye A.H. Phase I and Pharmacokinetic Study of Photodynamic Therapy for High Grade Gliomas Using a Novel Boronated Porphyrin (BOPP). Journal of Clinical Oncology 19: 519 - 524 (2001)
  25. Li, J., Turnidge, J., Milne, R., Nation, R.L. and Coulthard, K. In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa from cystic fibrosis patients. Antimicrobial Agents and Chemotherapy 45: 781 - 785 (2001)
  26. Shackleford, D.M., Hayball, P.J., Reynolds, G.D., Hamon, D.P.G., Evans, A.M., Milne, R.W. and Nation, R.L. A small-scale synthesis and enantiomeric resolution of 14C-(RS)-2-phenylpropionic acid and biosynthesis of its diastereomeric acyl glucuronides. Journal of Labelled Compounds and Radiopharmaceutical 44: 225 – 234 (2001)
  27. Li, J., Milne, R.W., Nation, R.L., Turnidge, J.D., Coulthard, K. and Johnson, D.W. A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reverse-phase high-performance liquid chromatography. Journal of Chromatography: Biomedical Applications 761: 167 – 175 (2001)
  28. Mancinelli A, Longo A, Nation RL, Evans AM. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. Drug Metab Dispos. 28: 1401-4 (2000).
  29. Evans AM, Faull R, Fornasini G, Lemanowicz EF, Longo A, Pace S, Nation RL. Pharmacokinetics of L-carnitine in patients with end-stage renal disease undergoing long-term hemodialysis. Clin Pharmacol Ther. 68: 238-49 (2000)
  30. Sabordo L, Sallustio BC, Evans AM, Nation RL. Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-beta-D-glucuronide: effects of clofibric acid, acetaminophen, and acetaminophen glucuronide. J Pharmacol Exp Ther. 295: 44-50 (2000)
  31. Van Crugten JT, Somogyi AA, Nation RL. Effect of uranyl nitrate-induced renal failure on morphine disposition and antinociceptive response in rats. Clin Exp Pharmacol Physiol. 27: 74-9 (2000)
  32. Evans AM, O'Brien J, Nation RL. Application of a loading wash-out method for investigating the hepatocellular efflux of a hepatically-generated metabolite, morphine-3-glucuronide. J Pharm Pharmacol. 51: 1289-97 (1999)
  33. Sabordo L, Sallustio BC, Evans AM, Nation RL. Hepatic disposition of the acyl glucuronide1-O-gemfibrozil-beta-D-glucuronide: effects of dibromosulfophthalein on membrane transport and aglycone formation. J Pharmacol Exp Ther. 288: 414-20 (1999)
  34. Kirkwood LC, Nation RL, Somogyi AA. Glucuronidation of dihydrocodeine by human liver microsomes and the effect of inhibitors. Clin Exp Pharmacol Physiol. 25: 266-70 (1998)
  35. Nation, R.L., Evans, A.M., Cabot, J.L., Shanahan, K.M. and Hsyu, P-H. Effect of cationic drugs on the renal secretion of ranitidine in the rat isolated perfused kidney. Clinical and Experimental Pharmacology and Physiology 25: 33 - 37 (1998)

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