|
|
|
Victorian College of Pharmacy Research
Pharmaceutical biotechnology
Research programmes in pharmaceutical biotechnology include applications of applied molecular cell biology in drug discovery, and programmes aimed at design of therapeutic biotechnology products.
The study of molecular cell biology is central to the identification of new targets for drug action, and the investigation of the molecular mechanisms of drug action (molecular pharmacology). G protein-coupled receptors and their downstream signalling systems are a primary focus, both for fundamental studies and direct drug discovery projects. Our research programmes use cell culture models as the basis for mechanistic studies using ligand binding, microscopic and electrophysiological methods, and these studies are often linked to tissue or in vivo studies by collaboration, both within the faculty and outside. The growth of fully differentiated cells from human stem cells has the potential to provide excellent models for drug discovery. The pharmacology of neurons derived from stem cells is being investigated, and opportunities for discovery of regenerative drugs offers much potential for the future.
Delivery of macromolecules, such as proteins, RNA derivatives, and DNA, are dependent on an understanding of membrane transport and intracellular trafficking. Macromolecules and viruses often take advantage of active mechanisms, which could also be harnessed for use in pharmaceutical products, and are being investigated with gene therapy, antisense, RNA inhibition, and immunotherapy in mind.
Pharmaceutical proteins are becoming increasingly important in regulation of the immune system and treatment of auto-immune diseases. The department has particular interest in discovery of agents for treatment of rheumatoid arthritis.
Pharmaceutical biotechnology research activities
|
