Trent Ashton's Project
The Design and Synthesis of Novel N6-Subsititued and 5'-Modified Adenosines.
Previous group research has led to the development of compounds which are extremely potent and selective for human adenosine A1 receptors. These compounds have been developed as leads for improved anti-arrhythmic agents. This project involves the design, synthesis and evaluation of a series of N6-substituted adenosines (figure 1) as potential selective agonists for adenosine A1 receptor. Modifications to the 5'-position of the ribose moiety (figure 1) are also being investigated as potential partial agonist for the A1 receptor.
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